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高血压并房颤与同型半胱氨酸、踝臂指数的相关性(2)

人气指数: 发布时间:2014-11-11 11:30  来源:http://www.zgqkk.com  作者: 孙国锋等
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  有研究表明,心血管疾病的预后在有房颤的患者中比无房颤的患者更差[10]。还有研究表明,有房颤的心血管病患者相比无房颤的患者来说,更易有低ABI和PAD的可能性[10]。

  据相关研究报道,ABI是一个独立的未来心血管事件的独立预测因素,ABI评估和相关的治疗也许对预防未来进一步的心血管事件有很大的影响[13-14]。

  德国Lange等[15]在一个周期一年的前瞻性队列研究中表明,有着低ABI的患者全因死亡的风险增加,低ABI与高Hcy水平联合检测有助于鉴别出高危患者。ABI与Hcy联合检测对高血压并房颤患者可以较好地预测脑卒中的发生风险。

  参考文献

  [1] Wijffels M C,Kirchhof C J,Dorland R,et al.Atrial fibrillation begets atrial fibrillation.A study in awake chronically instrumented goats[J].Circulation,1995,92(7):1954-1968.

  [2]陈灏珠 心房颤动诊断与治疗的进展和展望[J].中国实用内科杂志,2006,26(2):82-85.

  [3] David Conen Birth. Weight is a significant risk factor for incident atrial fibrillation[J]. Circulation,2010, 122(8): 764-770.

  [4] Alvaro Alons. Chronic kidney disease is associated with the incidence of atrial fibrillation: the Atherosclerosis Risk in Communities(ARIC) Study[J].Circulation, 2011, 123(25): 2946-2953.

  [5] David Conen. Influence of systolic and diastolic blood pressure on the risk of incident atrial fibrillation in women[J].Circulation, 2009 ,119(16): 2146-2152.

  [6] Tayama J,Munakata M,Yoshinaga K,et al.Higher plasma homocysteine concentrations associated with more advanced systemic arterial stiffness and greater blood pressure response to stress in hypertensive patients[J].Hypertens Res,2006,9(6):403-409.

  [7] Bhatt D L, Wilson P W, D’Agostino R Sr, et al. REACH Registry Investigators. One year cardiovascular event rates in outpatients with atherothrombosis[J].JAMA,2007,297(11):1197-1206.

  [8] Mkenna M, Wolson S, Kuller L. The ratio of ankle and arm arterial pressure as an independent predictor of mortality[J]. Atherosclerosis, 1991,87(45):119-128.

  [9] Gallego P, Roldán V, Marín F, et al. Ankle brachial index as an independent predictor of mortality in anticoagulated atrial fibrillation[J]. European Journal of Clinical Investigation,2012,42(12):1302–1308.

  [10] Edita Ma?anauskien?, Albinas Naud?iūnas. Comparison of Ankle-Brachial Index in Patients With and Without Atrial Fibrillation[J]. Medicina (Kaunas),2011,47(12):641-645.

  [11] Bogdanski P, Ewa Milller-Kasprzak E, Pupek-Musialik D, et al. Homocysteine,atherosclerosis, and endothelial progenitor cells in hypertension[J]. Clin Chem Lab Med,2012,50(78):1107-1113.

  [12] Wustmann,K, Marco,B, Annika, et al. Additive effect of homocysteine- and cholesterol-lowering therapy on endothelium-dependent vasodilation in patients with cardiovascular disease[J]. Cardiovascular therapeutics,2012,30(46):1755-5922.

  [13] Belch J J, Topol E J, Agnelli G, et al. Critical issues in peripheral arterial disease detection and management[J]. Arch Inter Med,2003,163(8):884-892.

  [14] Hirsch A T, Criqui M H, Treat-Jacobson D, et al. Peripheral arterial disease detection, awareness, and treatment in primary care[J]. JAMA,2001,286(11):1317-1324.

  [15] Lange S, TrampischaH J,Haberlb R,et al. Excess 1-year cardiovascular risk in elderly primary care patients with a low ankle-brachial index (ABI) and high homocysteine level[J]. Atherosclerosis, 2005, 178(2): 351-357.

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